Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi

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Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi.

Trypanosoma evansi is a blood protozoan parasite of the genus Trypanosoma which is responsible for surra (Trypanosomosis) in domestic and wild animals. This study addressed apoptotic-like features in Trypanosoma evansi in vitro. The mechanism of parasite death was investigated using staurosporine as an inducing agent. We evaluated its effects through several cytoplasmic features of apoptosis, i...

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Trypanocidal activity of human plasma on Trypanosoma evansi in mice.

This study aimed to test an alternative protocol with human plasma to control Trypanosoma evansi infection in mice. Plasma from an apparently 27-year-old healthy male, blood type A+, was used in the study. A concentration of 100 mg.dL(-1) apolipoprotein L1 (APOL1) was detected in the plasma. Forty mice were divided into four groups with 10 animals each. Group A comprised uninfected animals. Mic...

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Trypanosoma Evansi Infections

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ژورنال

عنوان ژورنال: Revista do Instituto de Medicina Tropical de São Paulo

سال: 2012

ISSN: 0036-4665

DOI: 10.1590/s0036-46652012000200008